Publications in the past 5 years

Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure

Yerra VG, Batchu SN, Kaur H, Kabir MDG, Liu Y, Advani SL, Tran DT, Sadeghian S, Sedrak P, Billia F, Kuzmanov U, Gramolini AO, Qasrawi DO, Petrotchenko EV, Borchers CH, Connelly KA, Advani A. The Journal of Clinical Investigation. 2023;133:e161453.

Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts

Kaur H, Yerra VG, Batchu SN, Tran DT, Kabir MDG, Liu Y, Advani SL, Sedrak P, Geldenhuys L, Tennankore KK, Poyah P, Siddiqi FS, Advani A. British Journal of Pharmacology. 2023;133:Epub ahead of print April 28.

The anti-hypertensive effects of sodium-glucose cotransporter-2 inhibitors.

Kugathasan L, Dubrofsky L, Advani A, Cherney DZI. Expert Reviews in Cardiovascular Therapy. 2023;21:15-34.

Sustained improvement in glycemic control in emerging adults with Type 1 diabetes 2 years after the start of the COVID-19 pandemic.

Swaich H, Advani A. Diabetes Therapy. 2023;14:153-165.

The SGLT2i dapagliflozin reduces RV mass independent of changes in RV pressure induced by pulmonary artery banding.

Connelly KA, Wu E, Visram A, Friedberg MK, Batchu SN, Yerra VG, Thai K, Nghiem L, Zhang Y, Kabir G, Desjardins JF, Advani A, Gilbert RE. Cardiovascular Drugs and Therapy. 2022; Epub ahead of print Sep 29.

DJ-1 binds to rubicon to impair LC-3 associated phagocytosis.

Gupta S, Amatullah H, Tsoporis JN, Wei K, Monteiro APT, Ektesabi AM, Varkouhi AK, Vaswani CM, Formosa A, Fabro AT, Batchu SN, Fjell C, Russell JA, Walley KR, Advani A, Parker TG, Marshall JC, Rocco PRM, Fairn GD, Mak TW, Dos Santos CC. Cell Death and Differentiation. 2022;29:2024-2033.

Role of CCR2-positive cardiac macrophages in pathological ventricular remodeling.

Yerra VG, Advani A. Biomedicines. 2022;10:661.

Perceptions and correlates of distress due to the COVID-19 pandemic and stress management strategies among people with diabetes: a mixed methods study.

Im J, Escudero C, Zhang K, Choi D, Sivakumar A, Booth GL, Sale J, Pritlove C, Advani A, Yu CH. Canadian Journal of Diabetes. 2022;46:253-261.

Empagliflozin disrupts a Tnfrsf12a-mediated feed forward loop trial that promotes left ventricular hypertrophy.

Yerra VG, Batchu SN, Kabir G, Advani SL, Liu Y, Siddiqi FS, Connelly KA, Advani A. Cardiovascular Drugs and Therapy. 2022;36:619-632

Lung and kidney ACE2 and TMPRSS2 in renin angiotensin system blocker treated comorbid diabetic mice mimicking host factors that have been linked to severe COVID-19.

Batchu SN, Kaur H, Yerra VG, Advani SL, Kabir MG, Liu Y, Klein T, Advani A. Diabetes. 2021;70:759-771.

Acute kidney injury: a bona fide complication of diabetes. Diabetes.

Advani A. Diabetes. 2020;69:2229-2237.

Experiences and perspectives of the parents of emerging adults living with type 1 diabetes.

Pritlove C, Markowitz B, Mukerji G, Advani A*, Parsons JA*. BMJ Open Diabetes Research and Care. 2020;e001125.

The dipeptidyl peptidase-4 inhibitor linagliptin directly enhances the contractile recovery of mouse hearts at a concentration equivalent to that achieved with standard dosing in humans.

Batchu SN, Yerra VG, Liu Y, Advani SL, Klein T, Advani A. IJMS 2020;21:E5757.

A common glomerular transcriptomic signature distinguishes diabetic kidney disease from other kidney diseases in humans and mice. Current Research in

Abdalla M, Abdalla M, Siddiqi FS, Geldenhuys L, Batchu SN, Tolosa MF, Yuen DA, Dos Santos CC, Advani A. Translational Medicine. 2020;S2452-3186:30034-30039.

Acute kidney injury: a bona fide complication of diabetes.

Advani A. Diabetes. 2020;69:2229-2237.

Experiences and perspectives of the parents of emerging adults living with type 1 diabetes.

Pritlove C, Markowitz B, Mukerji G, Advani A, Parsons JA. BMJ Open Diabetes Research and Care. 2020;8:e001125.

The dipeptidyl peptidase-4 inhibitor linagliptin directly enhances the contractile recovery of mouse hearts at a concentration equivalent to that achieved with standard dosing in humans.

Batchu SN, Yerra VG, Liu, Y, Advani SL, Klein T, Advani A. IJMS. 2020;21:E5757.

A common glomerular transcriptomic signature distinguishes diabetic kidney disease from other kidney diseases in humans and mice.

Abdalla M, Abdalla M, Siddiqi FS, Geldenhuys L, Batchu SN, Tolosa MF, Yuen DA, Dos Santos CC, Advani A. Current Research in Translational Medicine. 2020;S2452-3186:30034-30039.

Screening and treatment outcomes in adults and children With Type 1 Diabetes and asymptomatic celiac disease: The CD-DIET Study.

Mahmud FH, Clarke ABM, Joachim KC, Assor E, McDonald C, Saibil F, Lochnan HA, Punthakee Z, Parikh A, Advani A, Shah BR, Perkins BA, Zuijdwijk CS, Mack DR, Koltin D, De Melo EN, Hsieh E, Mukerji G, Gilbert J, Bax K, Lawson ML, Cino M, Beaton MD, Saloojee NA, Lou O, Gallego PH, Bercik P, Houlden RL, Aronson R, Kirsch SE, Paterson WG, Marcon MA. Diabetes Care. 2020;43:1553-1556.

Load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction.

Connelly KA, Zhang Y, Desjardins JF, Ngheim L, Visram A, Batch SN, Yerra VG, Kabir G, Thai K, Advani A, Gilbert RE. Cardiovascular Diabetology. 2020;19:13.

The endothelial barrier is not rate-limiting to insulin action in the myocardium of male mice.

Sanwal R, Khosraviani N, Advani SL, Advani A, Lee WL. Endocrinology. 2020;161:bqaa029. Feb 27.

Positioning time in range in diabetes management.

Advani A. Diabetologia. 2020;63:242-252.

Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease.

Majumder S, Hadden MJ, Thieme K, Batchu SN, Niveditha D, Chowdhury S, Yerra VG, Advani SL, Bowskill BB, Liu Y, Vakili H, Alghamdi TA, White KE, Geldenhuys L, Siddiqi FS, Advani A. Diabetologia. 2019;62:2129-2142.

The 3i conceptual framework for recognizing patient perspectives of Type 1 diabetes during emerging adulthood.

Markowtiz B, Pritlove C, Mukerji G, Lavery JA, Parsons JA, Advani A. JAMA Network Open. 2019;2:e196944.

Empagliflozin improves diastolic function in a nondiabetic rodent model of heart failure with preserved ejection fraction.

Connelly KA, Zhang Y, Visram A, Advani A, Batchu SN, Desjardins JF, Thai K, Gilbert RE. JACC Basic to Translational Science. 2019;25:27-37.

Renal hemodynamic function and RAAS activation over the natural history of Type 1 diabetes.

Lytvyn Y, Bjornstad P, Lovshin JA, Boulet G, Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins BA, Cherney DZI. American Journal of Kidney Diseases. 2019;73:786-796.

Association between uric acid, renal hemodynamics and arterial stiffness over the natural history of type 1 diabetes.

Lytvyn Y, Bjornstad P, Lovshin JA, Singh SK, Boulet G, Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins BA, Cherney DZI. Diabetes, Obesity and Metabolism. 2019;21:1388-1398.

Histone H3 serine 10 phosphorylation facilitates endothelial activation in diabetic kidney disease.

Alghamdi TA, Batchu SN, Hadden MJ, Yerra VG, Liu Y, Bowskill BB, Advani SL, Geldenhuys L, Siddiqi FS, Majumder S, Advani A. Diabetes. 2018;67:2668-2681.

Histone deacetylase inhibitors and diabetic kidney disease.

Hadden MJ and Advani A. International Journal of Molecular Sciences. 2018;19:E2630.

The dipeptidyl peptidase 4 substrate CXCL2 has opposing cardiac effects in young mice and aged diabetic mice mediated by Ca2+ flux and phosphoinositide 3-kinase gamma.

Batchu SN, Thieme K, Zadeh FH, Alghamdi TA, Yerra VG, Hadden MJ, Majumder S, Kabir MG, Bowskill BB, Ladha D, Gramolini AO, Connelly KA, Advani A. Diabetes. 2018;67:2443-2455.

Histones and heart failure in diabetes.

Yerra VG and Advani A. Cellular and Molecular Life Sciences. 2018;75:3193-3123.

Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation.

Bugyei-Twum A, Ford C, Civitarese R, Seegobin J, Advani SL, Desjardins JF, Kabir G, Zhang Y, Mitchell M, Switzer J, Thai K, Shen V, Abadeh A, Singh KK, Billia F, Advani A, Gilbert RE, Connelly KA. Cardiovascular Research. 2018;114:1629-1641.

HDAC6 inhibition promotes transcription factor EB activation and is protective in experimental kidney disease.

Brijmohan AS, Batchu SN, Majumer S, Alghamdi TA, Thieme K, McGaugh S, Liu Y, Advani SL, Bowskill BB, Kabir MG, Geldenhuys L, Siddiqi FS, Advani A. Frontiers in Pharmacology. 2018;34:9.

Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease.

Majumder S, Thieme K, Batchu SN, Alghamdi TA, Bowskill BB, Kabir MG, Liu Y, Advani SL, White KE, Geldenhuys L, Tennankore KK, Poyah P, Siddiqi FS, Advani A. The Journal of Clinical Investigation. 2018;128:483-499.

Dapagliflozin in focal segmental glomerulosclerosis: a combined human-rodent pilot study.

Rajesakaran H, Reich HN, Hladunewich MA, Cattran D, Lovshin JA, Lytvyn Y, Bjornstad P, Lia V, Tse J, Cham L, Majumder S, Bowskill BB, Kabir MG, Gibson IW, Sood MM, Advani A, Cherney DZI. American Journal of Physiology- Renal Physiology. 2018;314:F412-F422.