Pressure overload induces ISG15 to facilitate adverse
ventricular remodeling and promote heart failure
Yerra VG, Batchu SN, Kaur H, Kabir MDG, Liu Y, Advani
SL, Tran DT, Sadeghian S, Sedrak P, Billia F, Kuzmanov
U, Gramolini AO, Qasrawi DO, Petrotchenko EV, Borchers
CH, Connelly KA, Advani A. The Journal of Clinical Investigation. 2023;133:e161453.
Single cell G-protein coupled receptor profiling of
Transcription factor 21 expressing activated kidney
fibroblasts
Kaur H, Yerra VG, Batchu SN, Tran DT, Kabir MDG, Liu Y,
Advani SL, Sedrak P, Geldenhuys L, Tennankore KK, Poyah
P, Siddiqi FS, Advani A. British Journal of Pharmacology. 2023;133:Epub ahead of print April 28.
The anti-hypertensive effects of sodium-glucose
cotransporter-2 inhibitors.
Kugathasan L, Dubrofsky L, Advani A, Cherney DZI. Expert Reviews in Cardiovascular Therapy. 2023;21:15-34.
Sustained improvement in glycemic control in emerging
adults with Type 1 diabetes 2 years after the start of
the COVID-19 pandemic.
Swaich H, Advani A. Diabetes Therapy. 2023;14:153-165.
The SGLT2i dapagliflozin reduces RV mass independent of
changes in RV pressure induced by pulmonary artery
banding.
Connelly KA, Wu E, Visram A, Friedberg MK, Batchu SN,
Yerra VG, Thai K, Nghiem L, Zhang Y, Kabir G, Desjardins
JF, Advani A, Gilbert RE. Cardiovascular Drugs and Therapy. 2022;
Epub ahead of print Sep 29.
DJ-1 binds to rubicon to impair LC-3 associated
phagocytosis.
Gupta S, Amatullah H, Tsoporis JN, Wei K, Monteiro APT,
Ektesabi AM, Varkouhi AK, Vaswani CM, Formosa A, Fabro
AT, Batchu SN, Fjell C, Russell JA, Walley KR, Advani A,
Parker TG, Marshall JC, Rocco PRM, Fairn GD, Mak TW, Dos
Santos CC. Cell Death and Differentiation. 2022;29:2024-2033.
Role of CCR2-positive cardiac macrophages in
pathological ventricular remodeling.
Yerra VG, Advani A. Biomedicines. 2022;10:661.
Perceptions and correlates of distress due to the
COVID-19 pandemic and stress management strategies among
people with diabetes: a mixed methods study.
Im J, Escudero C, Zhang K, Choi D, Sivakumar A, Booth
GL, Sale J, Pritlove C, Advani A, Yu CH. Canadian Journal of Diabetes. 2022;46:253-261.
Empagliflozin disrupts a Tnfrsf12a-mediated feed forward
loop trial that promotes left ventricular hypertrophy.
Yerra VG, Batchu SN, Kabir G, Advani SL, Liu Y, Siddiqi
FS, Connelly KA, Advani A. Cardiovascular Drugs and Therapy. 2022;36:619-632
Lung and kidney ACE2 and TMPRSS2 in renin angiotensin
system blocker treated comorbid diabetic mice mimicking
host factors that have been linked to severe COVID-19.
Batchu SN, Kaur H, Yerra VG, Advani SL, Kabir MG, Liu Y,
Klein T, Advani A. Diabetes. 2021;70:759-771.
Acute kidney injury: a bona fide complication of
diabetes. Diabetes.
Advani A. Diabetes. 2020;69:2229-2237.
Experiences and perspectives of the parents of emerging
adults living with type 1 diabetes.
Pritlove C, Markowitz B, Mukerji G, Advani A*, Parsons
JA*. BMJ Open Diabetes Research and Care. 2020;e001125.
The dipeptidyl peptidase-4 inhibitor linagliptin
directly enhances the contractile recovery of mouse
hearts at a concentration equivalent to that achieved
with standard dosing in humans.
Batchu SN, Yerra VG, Liu Y, Advani SL, Klein T, Advani
A. IJMS 2020;21:E5757.
A common glomerular transcriptomic signature
distinguishes diabetic kidney disease from other kidney
diseases in humans and mice. Current Research in
Abdalla M, Abdalla M, Siddiqi FS, Geldenhuys L, Batchu
SN, Tolosa MF, Yuen DA, Dos Santos CC, Advani A. Translational Medicine. 2020;S2452-3186:30034-30039.
Acute kidney injury: a bona fide complication of
diabetes.
Advani A. Diabetes. 2020;69:2229-2237.
Experiences and perspectives of the parents of emerging
adults living with type 1 diabetes.
Pritlove C, Markowitz B, Mukerji G, Advani A, Parsons
JA. BMJ Open Diabetes Research and Care. 2020;8:e001125.
The dipeptidyl peptidase-4 inhibitor linagliptin
directly enhances the contractile recovery of mouse
hearts at a concentration equivalent to that achieved
with standard dosing in humans.
Batchu SN, Yerra VG, Liu, Y, Advani SL, Klein T, Advani
A. IJMS. 2020;21:E5757.
A common glomerular transcriptomic signature
distinguishes diabetic kidney disease from other kidney
diseases in humans and mice.
Abdalla M, Abdalla M, Siddiqi FS, Geldenhuys L, Batchu
SN, Tolosa MF, Yuen DA, Dos Santos CC, Advani A. Current Research in Translational Medicine. 2020;S2452-3186:30034-30039.
Screening and treatment outcomes in adults and children
With Type 1 Diabetes and asymptomatic celiac disease:
The CD-DIET Study.
Mahmud FH, Clarke ABM, Joachim KC, Assor E, McDonald C,
Saibil F, Lochnan HA, Punthakee Z, Parikh A, Advani A,
Shah BR, Perkins BA, Zuijdwijk CS, Mack DR, Koltin D, De
Melo EN, Hsieh E, Mukerji G, Gilbert J, Bax K, Lawson
ML, Cino M, Beaton MD, Saloojee NA, Lou O, Gallego PH,
Bercik P, Houlden RL, Aronson R, Kirsch SE, Paterson WG,
Marcon MA. Diabetes Care. 2020;43:1553-1556.
Load-independent effects of empagliflozin contribute to
improved cardiac function in experimental heart failure
with reduced ejection fraction.
Connelly KA, Zhang Y, Desjardins JF, Ngheim L, Visram A,
Batch SN, Yerra VG, Kabir G, Thai K, Advani A, Gilbert
RE. Cardiovascular Diabetology. 2020;19:13.
The endothelial barrier is not rate-limiting to insulin
action in the myocardium of male mice.
Sanwal R, Khosraviani N, Advani SL, Advani A, Lee WL. Endocrinology. 2020;161:bqaa029.
Feb 27.
Positioning time in range in diabetes management.
Advani A. Diabetologia. 2020;63:242-252.
Dysregulated expression but redundant function of the
long non-coding RNA HOTAIR in diabetic kidney disease.
Majumder S, Hadden MJ, Thieme K, Batchu SN, Niveditha D,
Chowdhury S, Yerra VG, Advani SL, Bowskill BB, Liu Y,
Vakili H, Alghamdi TA, White KE, Geldenhuys L, Siddiqi
FS, Advani A. Diabetologia. 2019;62:2129-2142.
The 3i conceptual framework for recognizing patient
perspectives of Type 1 diabetes during emerging
adulthood.
Empagliflozin improves diastolic function in a
nondiabetic rodent model of heart failure with preserved
ejection fraction.
Connelly KA, Zhang Y, Visram A, Advani A, Batchu SN,
Desjardins JF, Thai K, Gilbert RE. JACC Basic to Translational Science. 2019;25:27-37.
Renal hemodynamic function and RAAS activation over the
natural history of Type 1 diabetes.
Lytvyn Y, Bjornstad P, Lovshin JA, Boulet G, Farooqi MA,
Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA,
Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins
BA, Cherney DZI. American Journal of Kidney Diseases. 2019;73:786-796.
Association between uric acid, renal hemodynamics and
arterial stiffness over the natural history of type 1
diabetes.
Lytvyn Y, Bjornstad P, Lovshin JA, Singh SK, Boulet G,
Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A,
Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett
E, Perkins BA, Cherney DZI. Diabetes, Obesity and Metabolism. 2019;21:1388-1398.
Alghamdi TA, Batchu SN, Hadden MJ, Yerra VG, Liu Y,
Bowskill BB, Advani SL, Geldenhuys L, Siddiqi FS,
Majumder S, Advani A. Diabetes. 2018;67:2668-2681.
Histone deacetylase inhibitors and diabetic kidney
disease.
Hadden MJ and Advani A. International Journal of Molecular
Sciences. 2018;19:E2630.
The dipeptidyl peptidase 4 substrate CXCL2 has opposing
cardiac effects in young mice and aged diabetic mice
mediated by Ca2+ flux and phosphoinositide 3-kinase
gamma.
Batchu SN, Thieme K, Zadeh FH, Alghamdi TA, Yerra VG,
Hadden MJ, Majumder S, Kabir MG, Bowskill BB, Ladha D,
Gramolini AO, Connelly KA, Advani A. Diabetes. 2018;67:2443-2455.
Histones and heart failure in diabetes.
Yerra VG and Advani A. Cellular and Molecular Life Sciences. 2018;75:3193-3123.
Sirtuin 1 activation attenuates cardiac fibrosis in a
rodent pressure overload model by modifying Smad2/3
transactivation.
Bugyei-Twum A, Ford C, Civitarese R, Seegobin J, Advani
SL, Desjardins JF, Kabir G, Zhang Y, Mitchell M, Switzer
J, Thai K, Shen V, Abadeh A, Singh KK, Billia F, Advani
A, Gilbert RE, Connelly KA. Cardiovascular Research. 2018;114:1629-1641.
HDAC6 inhibition promotes transcription factor EB
activation and is protective in experimental kidney
disease.
Brijmohan AS, Batchu SN, Majumer S, Alghamdi TA, Thieme
K, McGaugh S, Liu Y, Advani SL, Bowskill BB, Kabir MG,
Geldenhuys L, Siddiqi FS, Advani A. Frontiers in Pharmacology. 2018;34:9.
Shifts in podocyte histone H3K27me3 regulate mouse and
human glomerular disease.
Majumder S, Thieme K, Batchu SN, Alghamdi TA, Bowskill
BB, Kabir MG, Liu Y, Advani SL, White KE, Geldenhuys L,
Tennankore KK, Poyah P, Siddiqi FS, Advani A. The Journal of Clinical Investigation. 2018;128:483-499.
Dapagliflozin in focal segmental glomerulosclerosis: a
combined human-rodent pilot study.
Rajesakaran H, Reich HN, Hladunewich MA, Cattran D,
Lovshin JA, Lytvyn Y, Bjornstad P, Lia V, Tse J, Cham L,
Majumder S, Bowskill BB, Kabir MG, Gibson IW, Sood MM,
Advani A, Cherney DZI. American Journal of Physiology- Renal
Physiology. 2018;314:F412-F422.